This paper summarizes and presents the results of a unique collaboration between The Baltimore Museum of Art and the Imaging Research Center at the University of Maryland, Baltimore County, USA. The collaboration yielded a major visualization project that can be presented as both a real-time interactive simulation in the Museum’s galleries and a large-scale immersive experience. This visualization of interior living spaces that no longer exist provides a highly detailed record of how Dr. Claribel Cone and Miss Etta Cone, two wealthy Baltimore art collectors and patrons, filled their apartments with their incomparable collection of art by the French master Henri Matisse and other European post-Impressionist and modern artists. The experience provides a rich visual and historic context for museum visitors’ understanding and appreciation of the collection that now forms the cornerstone of The Baltimore Museum of Art’s permanent holdings.