This article introduces a theoretic model concerning the various forms of interfaces encountered in a Cultural Information System. Based on parameters, the potential cooperative relations of specialities participating in the process of Cultural Information System production provide a wide spectrum of interface forms, which could be approached through relative interpretative procedures, in physical, virtual or combined environments. The study of cultural content promotion methods, through an interdisciplinary approach, suggests new ways of information management, as well as new representation practices, which constitute the basis of new negotiation methodologies. Cultural Information Systems through a variety of possible interfaces, formed according to each given promotion strategy, suggest the study, within a broader research field, of new ways of information structure management, introducing new kinds of knowledge formation and consequently new interpretation tools of awareness. As a result of the interdisciplinary approach regarding Cultural Heritage management and subsequently of the possibility of parameterization regarding the forms of scientific fields and the practices of the specialities involved, a new design field is defined, the Cultural Information Interaction Design field. Major characteristic of this field is parameterizability; concerning both representation and interaction design models, as well as the design of information intake processes through sensorial approaches. The best application example of this model is found within the framework of contemporary exhibition design, where various representation methods and practices are gathered together constituting a uniform cultural post-environment. The particular nature of the design field concerned, as regards the ability of each given team of scientists to design and subsequently negotiate a wide spectrum of interfaces, makes it an interesting, and at the same time still un-explored design field, where experimental approaches of representation models can be examined in both physical and digital as well as in combined interaction environments.